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Home - Products - Others - Other Targets - β-CGRP, human TFA (101462-82-2 free base)

β-CGRP, human TFA (101462-82-2 free base)

CAS No. ——

β-CGRP, human TFA (101462-82-2 free base)( Human β-CGRP (TFA); CGRP-II (Human) (TFA) )

Catalog No. M29830 CAS No. ——

β-CGRP,human tissue is one of the calcitonin peptide, through complex behavior of calcitonin receptor like receptor (CRLR) - and receptor activity - modifying proteins (increased), and 1 and 300 - nM CRLR IC50s/RAMP1 and CRLR/RAMP2 cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    β-CGRP, human TFA (101462-82-2 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    β-CGRP,human tissue is one of the calcitonin peptide, through complex behavior of calcitonin receptor like receptor (CRLR) - and receptor activity - modifying proteins (increased), and 1 and 300 - nM CRLR IC50s/RAMP1 and CRLR/RAMP2 cells.
  • Description
    β-CGRP,human tissue is one of the calcitonin peptide, through complex behavior of calcitonin receptor like receptor (CRLR) - and receptor activity - modifying proteins (increased), and 1 and 300 - nM CRLR IC50s/RAMP1 and CRLR/RAMP2 cells.(In Vitro):β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2. CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Human β-CGRP (TFA); CGRP-II (Human) (TFA)
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    3907.38
  • Molecular Formula
    C164H268F3N51O50S3
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : ≥ 50 mg/mL (12.80 mM)
  • SMILES
    ——
  • Chemical Name
    Sequence:Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2(Disulfide bridge: Cys2-Cys7)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9.
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